ARL6

Disease Category: autosomal dominant
Patient Population: —
Clinical Trials: None found
Institution(s) Conducting Research: —

Where things stand · Treatment

Treatment options

None known

Where things stand · Clinical trials

Studies that may be relevant to review

Check current clinical trials for this gene — the Finder pulls live studies from ClinicalTrials.gov.

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Brief description

A clear, everyday-language overview of this gene.

ARL6 retinitis pigmentosa (RP) is a type of RP caused by a mutation in the ARL6 gene. ARL6, or ADP-ribosylation factor-like GTPase 6, is a protein that's part of the ARF family of proteins, which regulate cellular functions. RP is an inherited retinal dystrophy that causes a gradual loss of photoreceptors and retinal pigment epithelium, leading to blindness over several decades. Symptoms usually begin in childhood and include a narrowing of the visual field, or tunnel vision. In some cases, RP can progress to affect central vision. At present, there is no cure for RP, but treatments can help slow vision loss and restore some sight. RP can also cause other eye problems that can be treated, such as cataracts or swelling in the retina.

Support, accessibility and family guidance(the same for every gene)

This guidance applies to anyone living with an inherited retinal condition, whichever gene is involved. Anything specific to this gene is in the section above.

Ask before helping: People differ widely in what assistance they want, and it changes by task and by day. Asking first respects that, and avoids help that gets in the way.
Low-vision rehabilitation: Low-vision specialists work on practical skills and tools for the sight someone has — lighting, contrast, magnification, orientation and mobility.
Accessible technology: Screen readers, magnification, high-contrast modes and voice control are built into phones and computers. Small settings changes often help sooner than new equipment.
School and work: Accommodations are often available well before vision loss is severe. Starting the conversation early usually makes it easier.
Emotional and community support: A genetic result affects the whole family. Connecting with others living with RP helps people feel less alone with it.
Genetic counselling: A genetic counsellor can explain what a result means for relatives, and what testing options exist, without anyone being pushed into a decision.

Last reviewed: not yet reviewedReviewer: —

Medical disclaimer: This page is for education and navigation only — not medical advice, diagnosis, or treatment. These summaries are paraphrases of published research; always confirm details with a qualified clinician and primary sources.